Umberto M. Musazzi
UNIVERSITÀ DEGLI STUDI DI MILANO
Umberto M. Musazzi holds a PhD in pharmaceutical technology and legislation in 2014 and is currently a Fixed-term Research Fellow B at the Department of Pharmaceutical Sciences, University of Milan (Italy). As part of his research activity, he studies nanotechnological drug delivery systems for (trans-)dermal and intratympanic administration. Moreover, his research interests also include the analysis of the European regulatory framework on nanomedicines products and other non-biological complex drugs. He is co-author of 64 publications in international peer-review journals, 4 book chapters, and more than 60 communications in national and international congresses.
Diego Alejandro Dri
AGENZIA ITALIANA DEL FARMACO
To be confirmed.
Diego Alejandro Dri is an assessor at the Clinical Trials Office of the Italian Medicines Agency (AIFA). As a synthetic organic chemist, he was involved in the design and synthesis of active pharmaceutical drug substances, extending soon the expertise to the field of clinical trials where he has been working for 20 years both in private and public sectors. Since 2015 he is involved in the evaluation of clinical trials of medicinal products for human use and in the management of scientific and regulatory activities related to clinical trials assessment and authorization.
Dr. Dora Mehn is a scientific project officer at the Consumer Products Safety Unit of the European Commission's Joint Research Centre in Ispra, Italy. She received her PhD in Environmental Chemistry from the University of Szeged, Hungary. She worked on different nano and in vitro related projects for universities, biotech industry, and private research foundation. Since 2014 she works on particle characterisation using various size separation and measurement methods including asymmetric and centrifugal field flow fractionation and analytical ultracentrifugation.
ISTITUTO ITALIANO DI TECNOLOGIA
Giovanna Peruzzi is Technologist at Istituto Italiano di Tecnologia, Center for Life Nano- & Neuro-Science in Rome, Italy. She leads the Flow Cytometry Laboratory supporting the scientific projects of the center and to serve as a facility for outside the institute. Due to her expertise in cell biology and immunology, she is involved in several collaborations. She acts as biological referent of microfluidic and computational projects of the Center.
Simone De Panfilis
ISTITUTO ITALIANO DI TECNOLOGIA
S. De Panfilis graduated in Physics at the University of Rome Sapienza and got his PhD in Material Science at University of Paris VI. After several years at the European Synchrotron Radiation Faciliy in
Grenoble (France), he joined the Centre for Life Nano- & Neuro-Science of the Istituto Italiano di Tecnologia where he is currently head of the Imaging Facility.
ISTITUTO SUPERIORE DI SANITÀ
Francesca Marzoli is Researcher at the National Centre for Control and evaluation of medicines of the Istituto Superiore di Sanità. She carry out laboratory activities aimed at controlling the quality of different drugs and research activities aimed at the pharmacological characterization of new chemical species using in vitro and in vivo methods and of new drugs delivery system.
Universidad de Granada
César Viseras is Full Professor at the Department of Pharmacy and
Pharmaceutical Technology of University of Granada, Spain.
His scientific and technical expertise includes development and controls ofmedicinal products and medical devices including inorganic excipients. 130 cited papers, 7 book chapters and over 200 presentations at Conferences. Co-inventor of 2 patents.
G. Anselmi graduated in biotechnologies with a thesis in nanobiotechnologies and with a PhD in cellular biology. She is currently employed as product manager and field application scientist in Alfatest, an Italian distributor of high-end scientific instruments. During her PhD and later as a scientist in Novartis Vaccines & Diagnostics, now GSK Vaccines, Giulia developed skills in several fields of cellular and molecular biology, spanning from confocal microscopy to high throughput cloning and expression of proteins in different organisms. With a scientific background and experience both in research and sales, Giulia currently promotes the sale of high-end instruments for live imaging, single-cell proteomics and nanoparticles production, providing scientific consulting and application support to scientists all around Italy.
Simona Sennato is Researcher at the Institute of Complex Systems of the National Research Council. She got her Ph.D. in Physics in 2006 at University La Sapienza with an experimental thesis on electrostatic complexation phenomena in oppositely charged liposome-polyelectrolytes suspensions. Her research activity deals with Soft Matter and Biological Physics and she is expert in scattering and microscopic techniques; her current interests include the investigation of biomimetic systems and soft colloids with application in bio-nanotechnological field.
1st session chairman : S. Petralito - L. Di Marzio
Regulatory framework on nanotechnology products: how to strike a balance between innovation and public health (U. M. Musazzi - Università degli studi di Milano)
To be confirmed -
Critical Analysis and Quality Assessment of Nanomedicines and Nanocarriers in Clinical Trials
(D.A. Dri - AIFA)
Advanced nanomaterial size characterization methods: Examples and some standardization aspects
(D. Mehn - JRC ISPRA)
2nd session chairman : U. Musazzi - C. Viseras
Imaging and flow cytometry techniques for Nanocarriers characterization
(S. De Panfilis e G. Peruzzi - IIT)
Development of azithromycin-loaded microemulsions for the treatment of skin infection
(A. Abbruzzo - Università di Bologna
Thermosensitive Hydrogel loaded with Nanoparticles
for retinal delivery of Neuroprotective peptide
(I. Ottonelli - Univeristà di Modena e Reggio Emilia)
Nanocarriers for delivery of antinociceptive and anti-inflammatory agents
(F. Marzoli - Istituto Superiore di Sanità)
Continuous production and quantification of Nanoparticles and liposomes with microfluidics and DLS
(G. Anselmi - ALFATEST)
Lunch session (poster session)
3rd session chairman : F. Rinaldi - G. Poce
Plenary: Preparation of Nanocarriers
(C. Viseras - Universidad de Granada)
Liposomes-based smart drug delivery nanosystems activated by Non-Thermal EM fields
(L. Caramazza - Sapienza Università di Roma)
Hydrophilic functionalized silver nanoparticles for sustainable applications in agri-food
(S. Cerra - Sapienza Università di Roma)
Design and development of inhaled formulations for pulmonary drug delivery
(M. Puccetti - Università di Perugia)
Unveiling drug-lipid interaction in isoniazid-loaded
HSPC-DPPG liposomes for antitubercular therapy
(Simona Sennato - CNR-ISC)
Title to be defined
(A. Prina Mello - University of Dublin)
Conclusions, greetings and thanks
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Department of Drug Chemistry and Technologies
The Faculty of Pharmacy of Rome was officially established in 1932. The Department is inspired by the cultural values that have always distinguished the chemical sciences in general and the analysis of the development of pharmaceutical interest compounds in its many aspects.
One of the main objectives pursued is to contribute to the widening of knowledge in the field of basic research, fundamental cultural investment to set up qualified research aimed at both the development in the pharmaceutical and food sectors, thus able to realize the conditions for an effective transfer technological.
The research activity of the Nanomedicine_Lab is mainly involved in preparation and characterization of innovative drug delivery systems with application in therapeutic, diagnostic and theranostic fields, by different administration routes.
The lab activity focus on the application of different preparation techniques of liposomes, niosomes, nanobubbles and nanoemulsions and their physical-chemical characterization.
In the last years, our research centred on brain delivery, with particular attention to develop nanocarriers able to trespass the Blood Brain Barrier, e.g. amphiphile-coated nanobubbles, or tailored to reach the brain by alternative route, such as nose-to-brain administration (N2B). These strategies provide promising alternatives that are able to ameliorate the treatment of brain disease.
Furthermore, particular attention in formulating nanocarriers and nanovectors is given to natural compounds such as essential oils and to stimuli-responsive molecules (e.g pH-sensitive peptides).